Description

[3,5-Bis(Difluoromethyl)-1H-Pyrazol-1-Yl]Acetic Acid is a specialized fluorinated pyrazole derivative that serves as a high-value synthetic intermediate. Its unique structure, featuring two difluoromethyl groups, makes it a critical building block for introducing fluorine motifs into target molecules, which is essential for modulating the physicochemical and biological properties of advanced materials and active ingredients. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel compounds with enhanced metabolic stability, bioavailability, and activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology, antiviral, and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the difluoromethyl group improves lipophilicity and environmental stability.
• Material Science Research: Serves as a precursor for fluorinated polymers, liquid crystals, or organic electronic materials that require specific dielectric properties or chemical resistance.
• Chemical Biology Probes: Utilized in the design of fluorinated probes and tags for studying enzyme mechanisms and protein-ligand interactions via 19F NMR spectroscopy.
• Custom Synthesis & Contract Manufacturing: A pivotal intermediate for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	[3,5-Bis(Difluoromethyl)-1H-Pyrazol-1-Yl]Acetic Acid
CAS No.	512809-60-8
Molecular Formula	C7H6F4N2O2
Molecular Weight	226.13 g/mol
Synonyms	(3,5-Bis(difluoromethyl)-1H-pyrazol-1-yl)acetic acid; 1H-Pyrazole-1-acetic acid, 3,5-bis(difluoromethyl)-; 2-[3,5-Bis(difluoromethyl)pyrazol-1-yl]acetic acid; 3,5-Difluoromethyl-1H-pyrazole-1-acetic acid; DFMPA; Bis(difluoromethyl)pyrazole acetic acid; Fluorinated pyrazole acetic acid derivative
EINECS	Contact for details

Quality Control

Every batch of [3,5-Bis(Difluoromethyl)-1H-Pyrazol-1-Yl]Acetic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the identity, purity, and consistency required for sensitive R&D and scale-up processes. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting critical parameters such as assay (HPLC), related substances, and residual solvents. Our quality commitment supports compliance with ISO 9001 standards and customer-specific regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its nature as a strong acid/organic solvent, ensure containers are kept upright and sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.