Description

D-Alanine, n-[(4-Methylphenyl)Sulfonyl]-, Methyl Ester is a specialized chiral sulfonamide derivative of D-alanine, serving as a high-value synthetic intermediate. This compound matters for its role in constructing complex molecules, particularly in the development of pharmaceuticals and advanced materials where stereochemical purity is critical. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of chiral active pharmaceutical ingredients (APIs), particularly protease inhibitors and other enzyme-targeted drugs.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in stereoselective reactions to introduce the D-alanine moiety into target molecules.
• Peptidomimetic Research: Employed in the design and synthesis of peptide analogs and mimetics for drug discovery programs.
• Agrochemical Development: Intermediate in the creation of novel, chiral herbicides and fungicides with improved efficacy and environmental profiles.
• Ligand Synthesis: Precursor for the preparation of specialized ligands used in catalysis and metal complexation.
• Academic & Contract Research: Valuable reagent for methodological development in organic chemistry and custom synthesis projects.

Basic Information

Product Name	D-Alanine, n-[(4-Methylphenyl)Sulfonyl]-, Methyl Ester
CAS No.	511286-68-3
Molecular Formula	C11H15NO4S
Molecular Weight	257.31 g/mol
Synonyms	D-Alanine, N-(p-toluenesulfonyl)-, methyl ester; Methyl N-(4-methylphenyl)sulfonyl-D-alaninate; Methyl (2R)-2-[(4-methylphenyl)sulfonylamino]propanoate; D-N-Tosylalanine methyl ester; (R)-Methyl 2-((4-methylphenyl)sulfonamido)propanoate; D-Alanine, N-tosyl-, methyl ester; Methyl (R)-2-(tosylamino)propanoate; Tos-D-Ala-OMe
EINECS	Contact for details

Quality Control

Our D-Alanine, n-[(4-Methylphenyl)Sulfonyl]-, Methyl Ester is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.