Description

3-(Trifluoroacetyl)Coumarin is a specialized fluorinated coumarin derivative, a high-value building block in advanced organic synthesis. This compound matters for its unique trifluoroacetyl functional group, which imparts distinct electronic and steric properties critical for developing novel materials and active molecules. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and materials science industries for applications ranging from fluorescent probes to the synthesis of complex heterocycles.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Fluorescent Probe & Sensor Development: Serves as a core structure for creating sensitive and selective fluorescent chemosensors due to the coumarin scaffold's inherent photophysical properties.
• Agrochemical Research: Used in the synthesis of new active ingredients for crop protection, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Organic Light-Emitting Diode (OLED) Materials: A precursor for electron-transport or emissive layer materials in advanced display technologies.
• Advanced Material Science: Building block for polymers and coatings with specific optical or surface properties.
• Academic & Industrial R&D: A versatile reagent for methodological studies in organic chemistry, including cyclization and fluorination reactions.

Basic Information

Product Name	3-(Trifluoroacetyl)Coumarin
CAS No.	503315-79-5
Molecular Formula	C₁₂H₅F₃O₃
Molecular Weight	254.16 g/mol
Synonyms	3-Trifluoroacetylcoumarin; 3-Trifluoroacetyl-2H-chromen-2-one; 2-Oxo-2H-chromene-3-carboxylic acid trifluoromethyl ketone; 3-(Trifluoroacetyl)-2H-1-benzopyran-2-one; Coumarin-3-trifluoromethyl ketone; 3-TFA-coumarin
EINECS	Contact for details

Quality Control

Our 3-(Trifluoroacetyl)Coumarin is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.