Description

Ethyl 1-Benzyl-4-(((Trifluoromethyl)Sulfonyl)Oxy)-1,2,5,6-Tetrahydropyridine-3-Carboxylate is a high-value trifluoromethanesulfonate (triflate) ester derivative, serving as a critical synthetic intermediate in advanced organic chemistry. This compound is prized for its excellent leaving group properties, enabling efficient cross-coupling and functional group transformations under mild conditions. It is primarily utilized by pharmaceutical and agrochemical R&D organizations for the synthesis of novel active ingredients and complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging the stability and reactivity of the triflate group.
• Cross-Coupling Reactions: Essential reagent in palladium-catalyzed reactions such as Suzuki, Stille, and Negishi couplings for carbon-carbon bond formation.
• Material Science Research: Intermediate in the creation of specialized organic materials and liquid crystals.
• Chemical Biology Probes: Serves as a precursor for labeling reagents and probe molecules used in biochemical assays.
• Process Chemistry & Scale-Up: Employed in route development and optimization for the commercial manufacturing of fine chemicals.

Basic Information

Product Name	Ethyl 1-Benzyl-4-(((Trifluoromethyl)Sulfonyl)Oxy)-1,2,5,6-Tetrahydropyridine-3-Carboxylate
CAS No.	500732-79-6
Molecular Formula	C₁₇H₁₈F₃NO₅S
Molecular Weight	405.39 g/mol
Synonyms	1-Benzyl-4-(((trifluoromethyl)sulfonyl)oxy)-1,2,5,6-tetrahydropyridine-3-carboxylic acid ethyl ester; Ethyl 1-benzyl-4-(trifluoromethanesulfonyloxy)-1,2,5,6-tetrahydropyridine-3-carboxylate; 1,2,5,6-Tetrahydropyridine-3-carboxylic acid, 1-benzyl-4-(((trifluoromethyl)sulfonyl)oxy)-, ethyl ester; 4-Triflyloxy-1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid ethyl ester; 1-Benzyl-4-trifluoromethanesulfonyloxy-3-ethoxycarbonyl-1,2,5,6-tetrahydropyridine
EINECS	Contact for details

Quality Control

Our Ethyl 1-Benzyl-4-(((Trifluoromethyl)Sulfonyl)Oxy)-1,2,5,6-Tetrahydropyridine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.