Description

Nα-[(Dimethylamino)Methylene]-L-Histidine Methyl Ester is a protected derivative of the essential amino acid L-Histidine, featuring a dimethylamino-methylene group at the Nα-position and a methyl ester. This compound is a crucial advanced pharmaceutical intermediate and a versatile building block in organic synthesis, designed to facilitate peptide coupling reactions while preventing unwanted side reactions. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams for the development of novel peptides, peptidomimetics, and bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate protected histidine residues into peptide chains.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or histidine-tagged molecules used in biochemical assays and diagnostic tools.
• Research & Development: Essential for academic and industrial research in medicinal chemistry, exploring new therapeutic targets involving histidine pathways.
• Catalyst & Ligand Synthesis: Potential starting material for synthesizing specialized ligands or organocatalysts due to its chelating imidazole moiety.

Basic Information

Product Name	Nα-[(Dimethylamino)Methylene]-L-Histidine Methyl Ester
CAS No.	59824-41-8
Molecular Formula	C10H18N4O2
Molecular Weight	226.28 g/mol
Synonyms	N(alpha)-[(Dimethylamino)methylene]-L-histidine methyl ester; L-Histidine, N-[(dimethylamino)methylene]-, methyl ester; (S)-Methyl 2-((dimethylamino)methyleneamino)-3-(1H-imidazol-4-yl)propanoate; N(α)-Dmab-L-His-OMe; Dmab-L-Histidine-OMe; Nα-(Dimethylaminomethylene)-L-histidine methyl ester; Fmoc-His(Dmab)-OH precursor; Protected L-Histidine methyl ester derivative
EINECS	Contact for details

Quality Control

Our Nα-[(Dimethylamino)Methylene]-L-Histidine Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification, to ensure it meets the high standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Contact for details
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.