Description

2,4,6-Triisopropylbenzenesulfonyltetrazole CAS NO 59128-88-0 is a specialized sulfonyl tetrazole derivative widely recognized as a key reagent in organic synthesis, particularly in nucleoside and oligonucleotide chemistry. Its primary value lies in its role as an efficient and selective activating agent for the phosphoramidite method of DNA and RNA synthesis, enabling the production of high-purity genetic material. This compound is essential for manufacturers and research institutions in the pharmaceutical, biotechnology, and diagnostic sectors who require reliable and high-quality building blocks for oligonucleotide production.

Application

• Oligonucleotide Synthesis: As a critical activator in the phosphoramidite solid-phase synthesis of DNA and RNA strands.
• Nucleoside Chemistry: Used in the preparation and modification of nucleosides and nucleotides for therapeutic and research applications.
• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) for antiviral and anticancer drugs.
• Probe and Primer Manufacturing: Essential for producing labeled probes, primers, and other synthetic oligonucleotides used in PCR, sequencing, and molecular diagnostics.
• Peptide Synthesis: Can be employed as a coupling reagent in certain segments of peptide synthesis protocols.
• Chemical Research: Utilized in academic and industrial R&D for developing new synthetic methodologies and novel biomolecules.

Basic Information

Product Name	2,4,6-Triisopropylbenzenesulfonyltetrazole
CAS No.	59128-88-0
Molecular Formula	C15H22N4O2S
Molecular Weight	322.43 g/mol
Synonyms	2,4,6-Triisopropylbenzenesulfonyl Tetrazole; TPS-Tetrazole; 1H-Tetrazole, 1-[(2,4,6-triisopropylphenyl)sulfonyl]-; 1-(2,4,6-Triisopropylbenzenesulfonyl)-1H-tetrazole; Tetrazole, 1-[(2,4,6-triisopropylphenyl)sulfonyl]-; TPS-T; Triisopropylbenzenesulfonyl Tetrazole; Activator for DNA Synthesis
EINECS	Contact for details

Quality Control

Our 2,4,6-Triisopropylbenzenesulfonyltetrazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.