Description

2-(Bromomethyl)-4-Chloro-1-Methoxybenzene is a versatile halogenated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its dual functionality, featuring both a reactive bromomethyl group and a chloro substituent on a methoxybenzene scaffold, enabling precise molecular construction. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating complex active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those with complex aromatic ether or substituted benzylamine structures.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides, where the chloro and bromomethyl groups allow for further functionalization.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized ligands used in metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the creation of novel organic electronic materials and liquid crystals due to its aromatic core and halogen handles.
• Custom Chemical Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring specific benzyl halide derivatives.
• Academic Research: A valuable reagent in university laboratories for methodological studies in halogenation, etherification, and nucleophilic substitution reactions.

Basic Information

Product Name	2-(Bromomethyl)-4-Chloro-1-Methoxybenzene
CAS No.	58735-58-3
Molecular Formula	C8H8BrClO
Molecular Weight	235.51 g/mol
Synonyms	4-Chloro-2-(bromomethyl)anisole; 1-Bromomethyl-4-chloro-2-methoxybenzene; 2-Bromomethyl-4-chloroanisole; (4-Chloro-2-methoxyphenyl)methyl bromide; 4-Chloro-α-bromo-o-anisylmethane; 2-Methoxy-5-chlorobenzyl bromide
EINECS	Contact for details

Quality Control

Our 2-(Bromomethyl)-4-Chloro-1-Methoxybenzene is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.