Description

1-(4-Nitrobenzenesulfonyl)-1H-1,2,4-Triazole is a specialized heterocyclic sulfonamide derivative, serving as a versatile and high-value synthetic building block in advanced organic chemistry. Its core value lies in its dual functionality, combining a reactive 1,2,4-triazole heterocycle with a 4-nitrobenzenesulfonyl protecting/activating group, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where it is utilized in the synthesis of active ingredients, intermediates, and novel chemical entities requiring specific heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing 1,2,4-triazole or sulfonamide moieties with potential biological activity.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its heterocyclic structure.
• Chemical Protecting Group: The 4-nitrobenzenesulfonyl (Nosyl) group acts as a protecting group for amines in multi-step synthetic sequences, especially in peptide and nucleotide chemistry.
• Organic Synthesis Reagent: Employed as a sulfonylation agent or electrophile in nucleophilic substitution reactions to introduce the Nosyl group into target molecules.
• Material Science Research: Investigated as a monomer or building block for creating functional polymers and advanced materials with specific electronic or thermal properties.
• Bioconjugation Chemistry: Potential use in linking biomolecules (e.g., proteins, peptides) with other entities for diagnostic or therapeutic applications.

Basic Information

Product Name	1-(4-Nitrobenzenesulfonyl)-1H-1,2,4-Triazole
CAS No.	57777-84-1
Molecular Formula	C8H6N4O4S
Molecular Weight	254.22 g/mol
Synonyms	1H-1,2,4-Triazole, 1-[(4-nitrophenyl)sulfonyl]-; 4-Nitrobenzenesulfonyl-1H-1,2,4-triazole; Nosyl-1,2,4-triazole; 1-(4-Nitro-phenylsulfonyl)-1H-[1,2,4]triazole; 1-(p-Nitrobenzenesulfonyl)-1H-1,2,4-triazole; 4-Nitro-N-(1H-1,2,4-triazol-1-yl)benzenesulfonamide; NSC 402108; 1,2,4-Triazole-1-sulfonic acid 4-nitro-phenyl ester
EINECS	Contact for details

Quality Control

Our 1-(4-Nitrobenzenesulfonyl)-1H-1,2,4-Triazole is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, IR) for structural confirmation, to ensure compliance with exacting standards for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and propensity for oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, especially after opening the original container. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.