Description

3β-tert-Butyldimethylsilyloxy Epiandrosterone is a key steroidal intermediate, specifically a silyl-protected derivative of epiandrosterone, which is essential for advanced pharmaceutical synthesis. This compound is valued for its role in modulating the reactivity and solubility of the parent steroid, enabling precise chemical transformations. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, including hormone modulators and other bioactive steroids.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new drug candidates targeting hormonal pathways.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of steroid derivatives, leveraging the protective group for selective reactions.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in steroid analysis.

Basic Information

Product Name	3β-tert-Butyldimethylsilyloxy Epiandrosterone
CAS No.	57711-44-1
Molecular Formula	C25H44O2Si
Molecular Weight	404.71 g/mol
Synonyms	3β-[(tert-Butyldimethylsilyl)oxy]epiandrosterone; 3β-TBDMS-O-Epiandrosterone; Epiandrosterone 3β-TBDMS ether; 5α-Androstan-3β-ol-17-one, 3-(1,1-dimethylethyl)dimethylsilyl ether; Androstan-17-one, 3-[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (3β,5α)-; 3β-Hydroxy-5α-androstan-17-one 3-tert-butyldimethylsilyl ether
EINECS	Contact for details

Quality Control

Our 3β-tert-Butyldimethylsilyloxy Epiandrosterone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.