Description

4-Methoxy-2-Nitrobenzyl Bromide is a versatile and high-purity organic bromide building block essential for advanced chemical synthesis. Its reactive benzyl bromide moiety makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is particularly valuable for medicinal chemists and process development scientists requiring reliable, high-quality raw materials for API development and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring a protected or functionalized benzyl group.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Peptide Chemistry: Serves as a protecting group reagent for carboxylic acids or as a precursor for specialized linkers in solid-phase peptide synthesis (SPPS).
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and photoactive polymers.
• Cross-Coupling Reactions: Acts as an electrophilic partner in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to introduce methoxy-nitrobenzyl motifs.
• Chemical Biology Probes: Utilized in the design and synthesis of photo-labile protecting groups ("caged compounds") for studying biological processes.

Basic Information

Product Name	4-Methoxy-2-Nitrobenzyl Bromide
CAS No.	57559-52-1
Molecular Formula	C8H8BrNO3
Molecular Weight	246.06 g/mol
Synonyms	1-(Bromomethyl)-4-methoxy-2-nitrobenzene; 2-Nitro-4-methoxybenzyl Bromide; 4-Methoxy-2-nitrobenzyl Bromide; 4-Methoxy-2-nitro-α-bromotoluene; (4-Methoxy-2-nitrophenyl)methyl Bromide; p-Methoxy-o-nitrobenzyl Bromide; α-Bromo-4-methoxy-2-nitrotoluene
EINECS	Contact for details

Quality Control

Our 4-Methoxy-2-Nitrobenzyl Bromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the stringent requirements of research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.