Description

3H-Pyrazol-3-One, 4-Chloro-1,2-Dihydro-5-Methyl-2-Phenyl-1-(Trimethylsilyl)- is a specialized organosilicon-protected pyrazolone derivative that serves as a critical synthetic intermediate. Its value lies in providing a protected, reactive handle for constructing complex heterocyclic frameworks, enabling precise chemical transformations. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced synthesis and route scouting.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic core.
• Material Science Precursor: Serves as a monomer or functionalization agent for creating specialized polymers and advanced materials.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for constructing complex molecules via cross-coupling and cyclization reactions.
• Chemical Biology Probe: Utilized in the development of molecular probes and inhibitors for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	3H-Pyrazol-3-One, 4-Chloro-1,2-Dihydro-5-Methyl-2-Phenyl-1-(Trimethylsilyl)-
CAS No.	57396-96-0
Molecular Formula	C13H17ClN2OSi
Molecular Weight	280.82 g/mol
Synonyms	4-Chloro-1,2-dihydro-5-methyl-2-phenyl-1-(trimethylsilyl)-3H-pyrazol-3-one; 4-Chloro-5-methyl-2-phenyl-1-(trimethylsilyl)pyrazol-3(2H)-one; 1-(Trimethylsilyl)-4-chloro-5-methyl-2-phenyl-1,2-dihydropyrazol-3-one; 57396-96-0; TMS-protected 4-chloropyrazolone; 1-Trimethylsilyl-4-chloro-5-methyl-2-phenylpyrazol-3-one
EINECS	Contact for details

Quality Control

Our production of 3H-Pyrazol-3-One, 4-Chloro-1,2-Dihydro-5-Methyl-2-Phenyl-1-(Trimethylsilyl)- adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong acids, bases, and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.