Description

3β,16α-Bis(Trimethylsiloxy)Pregn-5-En-20-One o-Methyl Oxime is a high-purity, organosilicon-protected steroid derivative, serving as a crucial advanced intermediate in pharmaceutical synthesis. Its primary value lies in enabling precise chemical transformations for the development of novel therapeutic agents, particularly in the field of endocrinology. This compound is essential for research institutions and pharmaceutical manufacturers focused on developing steroidal drugs, hormone analogs, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroidal active pharmaceutical ingredients (APIs).
• Hormone Analog Research: Used in the research and development of novel corticosteroids, progestins, and other hormone-related compounds.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of target steroid molecules.
• Academic & R&D: Utilized in university and institutional research for studying steroid chemistry, reaction mechanisms, and structure-activity relationships.

Basic Information

Product Name	3β,16α-Bis(Trimethylsiloxy)Pregn-5-En-20-One o-Methyl Oxime
CAS No.	57305-31-4
Molecular Formula	C28H51NO3Si2
Molecular Weight	505.89 g/mol
Synonyms	3β,16α-Bis(trimethylsilyloxy)pregn-5-en-20-one O-methyloxime; 3β,16α-Bis-O-(trimethylsilyl)pregnenolone methyloxime; Pregn-5-ene-3β,16α-diol, 20-one O-methyloxime, 3,16-bis(trimethylsilyl) ether; 3,16-Bis-O-TMS-pregnenolone methyloxime; 57305-31-4; Pregnenolone derivative, TMS-protected methyloxime
EINECS	Contact for details

Quality Control

Our 3β,16α-Bis(Trimethylsiloxy)Pregn-5-En-20-One o-Methyl Oxime is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.