Description

3β-[[2,6-Dideoxy-3-O,4-o-Bis(Trimethylsilyl)-D-Ribo-Hexopyranosyl]Oxy]-12β,14-Bis[(Trimethylsilyl)Oxy]-5β-Card-20(22)-Enolide is a key trimethylsilyl-protected intermediate in the synthesis of complex cardenolides and related steroidal compounds. This high-purity building block is critical for researchers and manufacturers requiring precise control over glycosylation and hydroxyl protection strategies in pharmaceutical development. It is primarily utilized in the research and production of specialized cardiac glycosides and other bioactive molecules within the pharmaceutical and fine chemical sectors.

Application

• Pharmaceutical Intermediate: Serves as a protected precursor in the multi-step synthesis of novel cardenolide drugs and analogs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the exploration of new therapeutic agents targeting cardiac function.
• Glycosylation Chemistry: Acts as a key substrate in stereoselective glycosylation reactions due to its protected sugar moiety.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Process Chemistry: Utilized in scaling up synthetic routes for complex natural product derivatives under controlled conditions.

Basic Information

Product Name	3β-[[2,6-Dideoxy-3-O,4-o-Bis(Trimethylsilyl)-D-Ribo-Hexopyranosyl]Oxy]-12β,14-Bis[(Trimethylsilyl)Oxy]-5β-Card-20(22)-Enolide
CAS No.	57304-67-3
Molecular Formula	C41H78O9Si4
Molecular Weight	827.43 g/mol
Synonyms	3β-[(2,6-Dideoxy-3,4-di-O-trimethylsilyl-α-L-ribo-hexopyranosyl)oxy]-12β,14-dihydroxy-5β-card-20(22)-enolide 12,14,3',4'-Tetrakis(trimethylsilyl) Ether; Digitoxigenin 3-O-(2,6-dideoxy-3,4-di-O-trimethylsilyl-α-L-ribo-hexopyranoside) 12,14-Bis(trimethylsilyl) Ether; 3-O-(2,6-Dideoxy-3,4-di-O-trimethylsilyl-α-L-ribo-hexopyranosyl)digitoxigenin 12,14-bis(trimethylsilyl) ether; Protected Digitoxigenin Glycoside; TMS-protected Cardenolide Intermediate
EINECS	Contact for details

Quality Control

Our 3β-[[2,6-Dideoxy-3-O,4-o-Bis(Trimethylsilyl)-D-Ribo-Hexopyranosyl]Oxy]-12β,14-Bis[(Trimethylsilyl)Oxy]-5β-Card-20(22)-Enolide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under inert atmosphere when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.