Description

(+)-(18-Crown-6)-2,3,11,12-Tetracarboxamide is a chiral, functionalized crown ether derivative of significant interest in advanced chemical synthesis and separation science. This compound matters for its exceptional ability to act as a highly selective host molecule, forming stable complexes with specific cations and chiral guests. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis, enantiomeric resolution, and as a key component in sensor technology and phase-transfer catalysis.

Application

• Chiral Phase-Transfer Catalyst: Enables enantioselective synthesis of amino acids and other chiral building blocks critical for pharmaceutical active ingredients.
• Enantiomeric Resolution Agent: Used in the separation of racemic mixtures via liquid-liquid extraction or as a chiral selector in chromatography.
• Ion-Selective Electrodes & Sensors: Serves as an ionophore in membrane electrodes for the potentiometric detection of specific alkali and ammonium cations.
• Molecular Recognition Studies: A valuable tool in supramolecular chemistry for investigating host-guest interactions and designing artificial receptors.
• Asymmetric Synthesis Facilitator: Promotes stereoselective reactions by creating chiral environments around reacting species.
• Polymer-Supported Catalyst Precursor: Can be immobilized on solid supports for use in reusable catalytic systems.

Basic Information

Product Name	(+)-(18-Crown-6)-2,3,11,12-Tetracarboxamide
CAS No.	57207-22-4
Molecular Formula	C20H28N4O10
Molecular Weight	484.46 g/mol
Synonyms	(+)-(18-Crown-6)-tetracarboxamide; (18-Crown-6)-2,3,11,12-tetracarboxylic acid tetraamide; (3aS,4S,7R,7aS,12S,13S,16R,16aS)-Dodecahydro-4,7,13,16-tetrakis(carbamoyl)-2H,11H-dibenzo[b,k][1,4,7,10,13,16]hexaoxacyclooctadecine; Chiral 18-Crown-6 tetracarboxamide; (S,S,S,S)-(+)-18-Crown-6-2,3,11,12-tetracarboxamide
EINECS	Contact for details

Quality Control

Our (+)-(18-Crown-6)-2,3,11,12-Tetracarboxamide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and specific rotation are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation [α]₂₀D	+30° to +35° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.