Description

Trimethyl[[(17R)-19-Norpregn-4-En-20-Yn-17-Yl]Oxy]Silane is a high-purity, organosilicon-protected steroid derivative, specifically designed for advanced pharmaceutical synthesis and research. This compound serves as a critical synthetic intermediate, offering a protected hydroxyl group to enable selective chemical transformations in complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology sectors for the development of novel therapeutic agents, particularly in steroid and hormone-related drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel steroid-based active pharmaceutical ingredients (APIs).
• Process Chemistry: Used in route scouting and optimization for the commercial-scale production of specialized steroid drugs.
• Medicinal Chemistry Research: Enables the exploration of new chemical entities (NCEs) by providing a versatile, protected functional group for further derivatization.
• Hormone Analog Development: Facilitates the synthesis of modified norpregnane derivatives for potential use in endocrine therapies.
• Chemical Biology Probes: Acts as a precursor for creating labeled or tagged steroid analogs used in biochemical and receptor binding studies.

Basic Information

Product Name	Trimethyl[[(17R)-19-Norpregn-4-En-20-Yn-17-Yl]Oxy]Silane
CAS No.	56771-62-1
Molecular Formula	C25H40OSi
Molecular Weight	384.68 g/mol
Synonyms	17β-[(Trimethylsilyl)oxy]-19-norpregn-4-en-20-yne; (17R)-17-[(Trimethylsilyl)oxy]-19-norpregn-4-en-20-yne; 19-Norpregn-4-en-20-yn-17-ol, 17-(trimethylsilyl) ether, (17R)-; Trimethyl((17R)-19-norpregn-4-en-20-yn-17-yloxy)silane; TMS Ether of 17β-Hydroxy-19-norpregn-4-en-20-yne; 17-TMS-19-norpregn-4-en-20-yne; Steroid TMS Ether Intermediate
EINECS	Contact for details

Quality Control

Our Trimethyl[[(17R)-19-Norpregn-4-En-20-Yn-17-Yl]Oxy]Silane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH Q7 guidelines for active pharmaceutical ingredients (APIs) and can provide material to meet specific customer requirements for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.