Description

Methyl 2-(Acetylamino)-3-O,4-O,6-o-Tris(Trimethylsilyl)-2-Deoxy-D-Glucopyranoside is a key protected carbohydrate derivative, specifically a per-silylated N-acetylglucosamine methyl glycoside, which serves as a crucial advanced intermediate in complex organic synthesis. Its value lies in providing a stable, reactive scaffold for the selective manipulation of hydroxyl groups, enabling the efficient construction of sophisticated glycoconjugates and oligosaccharides. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel glycosidase inhibitors, antiviral agents, and carbohydrate-based vaccines, as well as in academic research focused on glycochemistry and chemical biology.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of complex glycosidase inhibitors and antiviral drug candidates.
• Glycoconjugate Synthesis: Used in the preparation of neoglycoconjugates for immunological studies and vaccine development.
• Oligosaccharide Assembly: Serves as a key monomer in the iterative synthesis of defined oligosaccharide chains via selective deprotection strategies.
• Chemical Biology Probes: Employed in the creation of activity-based probes and metabolic labeling agents to study glycosylation processes.
• Chiral Pool Synthesis: Utilized as a chiral starting material or auxiliary for the asymmetric synthesis of non-carbohydrate natural products.
• Academic & R&D: Fundamental research tool in universities and corporate R&D labs for exploring new glycosylation methodologies and carbohydrate reactivity.

Basic Information

Product Name	Methyl 2-(Acetylamino)-3-O,4-O,6-o-Tris(Trimethylsilyl)-2-Deoxy-D-Glucopyranoside
CAS No.	56272-06-1
Molecular Formula	C20H45NO6Si3
Molecular Weight	503.83 g/mol
Synonyms	Methyl 2-Acetamido-3,4,6-tri-O-trimethylsilyl-2-deoxy-β-D-glucopyranoside; Methyl 2-Acetamido-2-deoxy-3,4,6-tri-O-(trimethylsilyl)-β-D-glucopyranoside; 2-Acetamido-3,4,6-tri-O-trimethylsilyl-2-deoxy-D-glucopyranose methyl glycoside; Per-O-trimethylsilylated N-Acetylglucosamine Methyl Glycoside; TMS-protected GlcNAc Methyl Glycoside; 1-O-Methyl-2-deoxy-2-acetamido-3,4,6-tri-O-trimethylsilyl-β-D-glucopyranose
EINECS	Contact for details

Quality Control

Our Methyl 2-(Acetylamino)-3-O,4-O,6-o-Tris(Trimethylsilyl)-2-Deoxy-D-Glucopyranoside is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized by advanced analytical techniques including NMR and HPLC to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, it is recommended to keep the product under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C to maintain stability. The compound is moisture-sensitive; ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.