Description

1-O,2-O,3-O,5-o-Tetrakis(trimethylsilyl)-D-xylofuranose is a highly functionalized, protected carbohydrate derivative, specifically a fully silylated form of D-xylofuranose. This compound is a critical advanced synthetic intermediate and protecting group reagent, valued for its role in complex organic synthesis. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the production of nucleoside analogs, carbohydrate-based drugs, and other bioactive molecules.

Application

• Nucleoside & Nucleotide Synthesis: A key protected intermediate in the synthesis of modified nucleosides for antiviral and anticancer drug development.
• Carbohydrate Chemistry: Serves as a versatile building block for the construction of complex oligosaccharides, glycoconjugates, and glycomimetics.
• Pharmaceutical Intermediates: Used in the multi-step synthesis of active pharmaceutical ingredients (APIs) where selective protection of hydroxyl groups is required.
• Protecting Group Reagent: The tetrakis(trimethylsilyl) groups provide robust protection for sensitive hydroxyl functionalities during complex synthetic sequences.
• Biochemical Research: Employed in the study of carbohydrate metabolism and enzyme inhibition as a substrate analog or inhibitor precursor.
• Chiral Pool Synthesis: Provides a source of chirality for the asymmetric synthesis of non-carbohydrate natural products and therapeutic agents.

Basic Information

Product Name	1-O,2-O,3-O,5-o-Tetrakis(trimethylsilyl)-D-xylofuranose
CAS No.	56271-68-2
Molecular Formula	C17H42O5Si4
Molecular Weight	452.88 g/mol
Synonyms	D-Xylofuranose, 1,2,3,5-tetrakis-O-(trimethylsilyl)-; 1,2,3,5-Tetra-O-trimethylsilyl-D-xylofuranose; Tetrakis(trimethylsilyl) D-xylofuranose; TMS-protected D-xylofuranose; 1,2,3,5-Tetrakis-O-(trimethylsilyl)-D-xylofuranose; Per-O-trimethylsilyl-D-xylofuranose; D-Xylofuranose tetrakis(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our high-purity 1-O,2-O,3-O,5-o-Tetrakis(trimethylsilyl)-D-xylofuranose is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.