Description

3α,19-Bis[(Trimethylsilyl)Oxy]-5α-Pregnan-20-One is a high-purity, protected steroid derivative, specifically a pregnane derivative with trimethylsilyl (TMS) ether groups at the 3α and 19 positions. This compound serves as a critical synthetic intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the synthesis of complex steroid-based active pharmaceutical ingredients (APIs) and for analytical method development.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroid hormones and related therapeutic agents.
• Reference Standard: Used for quality control, method validation, and calibration in analytical laboratories (HPLC, GC-MS, NMR).
• Process Chemistry: Employed in route scouting and optimization for the commercial-scale production of steroid-based pharmaceuticals.
• Biochemical Research: Utilized in studies investigating steroid metabolism, receptor binding, and enzymatic pathways as a protected substrate or analog.
• Fine Chemical Synthesis: Serves as a precursor for the preparation of more specialized steroid derivatives with modified biological activity.

Basic Information

Product Name	3α,19-Bis[(Trimethylsilyl)Oxy]-5α-Pregnan-20-One
CAS No.	56247-72-4
Molecular Formula	C₂₉H₅₂O₃Si₂
Molecular Weight	504.90 g/mol
Synonyms	3α,19-Bis(trimethylsiloxy)-5α-pregnan-20-one; 5α-Pregnan-20-one, 3α,19-bis[(trimethylsilyl)oxy]-; 3α,19-Bis-O-(trimethylsilyl)-5α-pregnan-20-one; 3α,19-Di-O-trimethylsilyl-5α-pregnan-20-one; 3α,19-Bis(trimethylsilyloxy)-5α-pregnan-20-one; 3α,19-Bis(TMS-O)-5α-pregnan-20-one; 3α,19-Di-TMS-5α-pregnan-20-one; 56247-72-4
EINECS	Contact for details

Quality Control

Our 3α,19-Bis[(Trimethylsilyl)Oxy]-5α-Pregnan-20-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assays and structural confirmation, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed batch-specific results are provided to guarantee traceability, consistency, and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.