Description

2-O,3-o-Dimethyl-4-O,5-o-Bis(Trimethylsilyl)-D-Ribose o-Methyl Oxime is a key protected ribose derivative, specifically designed as a sophisticated synthetic intermediate in advanced organic synthesis. Its value lies in providing a strategically blocked sugar scaffold that enables precise, multi-step chemical transformations while protecting sensitive hydroxyl groups. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the synthesis of nucleoside analogs, antiviral agents, and complex carbohydrate-based molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel nucleoside and nucleotide analogs with potential therapeutic activity.
• Antiviral Drug Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Carbohydrate Chemistry: Serves as a protected starting material for the preparation of complex oligosaccharides, glycoconjugates, and glycomimetics.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by allowing selective deprotection and functionalization at specific positions on the ribose ring.
• Process Chemistry & Scale-up: Provides a reliable, high-purity intermediate for optimizing synthetic routes from laboratory to pilot and commercial scale production.
• Bioconjugation & Probe Development: Facilitates the chemical synthesis of labeled nucleosides for diagnostic assays and biochemical research tools.

Basic Information

Product Name	2-O,3-o-Dimethyl-4-O,5-o-Bis(Trimethylsilyl)-D-Ribose o-Methyl Oxime
CAS No.	56196-37-3
Molecular Formula	C15H35NO4Si2
Molecular Weight	349.62 g/mol
Synonyms	D-Ribose, 2,3-di-O-methyl-4,5-bis-O-(trimethylsilyl)-, O-methyloxime; 2,3-Di-O-methyl-4,5-bis-O-(trimethylsilyl)-D-ribose O-methyloxime; 2,3-Di-O-methyl-4,5-di-O-(trimethylsilyl)-D-ribose methyloxime; Protected D-Ribose Oxime Derivative; TMS-protected Ribose Oxime
EINECS	Contact for details

Quality Control

Every batch of 2-O,3-o-Dimethyl-4-O,5-o-Bis(Trimethylsilyl)-D-Ribose o-Methyl Oxime is manufactured and tested under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specification parameters is provided with each shipment, supporting compliance in cGMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.