Description

(5S,6S)-4-Methoxy-5-Hydroxy-6-Phenethyl-5,6-Dihydro-2H-Pyran-2-One is a high-purity, chiral lactone compound of significant interest in advanced organic synthesis. Its defined stereochemistry and functional group array make it a valuable key chiral building block for the construction of complex molecular architectures. This compound is primarily sought after by research institutions and pharmaceutical development teams working on novel active pharmaceutical ingredients (APIs), natural product analogs, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of new therapeutic agents, particularly for complex target molecules.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric reactions to introduce stereochemical complexity.
• Natural Product Synthesis: Acts as a building block for the total or semi-synthesis of natural products containing dihydropyranone cores.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs.
• Process Chemistry Development: Used in scaling up synthetic routes for potential API candidates during process optimization stages.
• Reference Standard: Provides a high-purity standard for analytical method development and quality control in related chemical processes.

Basic Information

Product Name	(5S,6S)-4-Methoxy-5-Hydroxy-6-Phenethyl-5,6-Dihydro-2H-Pyran-2-One
CAS No.	56083-47-7
Molecular Formula	C₁₄H₁₆O₄
Molecular Weight	248.28 g/mol
Synonyms	(5S,6S)-4-Methoxy-5-hydroxy-6-phenethyl-5,6-dihydro-2H-pyran-2-one; 4-Methoxy-5-hydroxy-6-phenethyl-5,6-dihydro-2H-pyran-2-one, (5S,6S)-; (5S,6S)-6-Phenethyl-4-methoxy-5-hydroxy-5,6-dihydro-2H-pyran-2-one; 5,6-Dihydro-4-methoxy-5-hydroxy-6-(2-phenylethyl)-2H-pyran-2-one, (5S,6S)-; Chiral Dihydropyranone Lactone; Phenethyl Dihydropyranone Derivative
EINECS	Contact for details

Quality Control

Our (5S,6S)-4-Methoxy-5-Hydroxy-6-Phenethyl-5,6-Dihydro-2H-Pyran-2-One is produced under strict quality management protocols. Each batch undergoes comprehensive analytical characterization, including chiral purity verification by HPLC, to ensure high stereochemical and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and should be handled with care to avoid prolonged exposure to strong alkali/organic solvent conditions. Keep the container tightly sealed when not in use to maintain integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.