Description

(E)-1-[(1R,4S)-2,6,6-Trimethyl-7-oxabicyclo[2.2.1]hept-2-en-1-yl]-2-buten-1-one is a high-purity, optically active bicyclic ketone with a distinctive woody, amber-like character. This compound matters as a key chiral intermediate and fragrance ingredient, prized for its structural complexity and defined stereochemistry. It is needed by manufacturers in the flavor & fragrance industry for creating sophisticated aromas, and by pharmaceutical R&D teams for developing novel synthetic pathways.

Application

• Fragrance & Flavor Ingredient: Serves as a valuable building block for synthesizing complex amber, woody, and musk odorants in perfumery and flavor compositions.
• Pharmaceutical Intermediate: Utilized as a chiral synthon in the research and development of active pharmaceutical ingredients (APIs) requiring specific stereochemical configurations.
• Organic Synthesis Reagent: Acts as a specialized starting material or intermediate in advanced organic synthesis, particularly for constructing complex bicyclic frameworks.
• Fine Chemical Production: Employed in the manufacture of other high-value fine chemicals where its unique oxabicyclic structure is integral to the target molecule.
• Research & Development: Used in academic and industrial R&D settings for studying reaction mechanisms, catalysis, and the properties of strained ring systems.

Basic Information

Product Name	(E)-1-[(1R,4S)-2,6,6-Trimethyl-7-oxabicyclo[2.2.1]hept-2-en-1-yl]-2-buten-1-one
CAS No.	56083-36-4
Molecular Formula	C14H20O2
Molecular Weight	220.31 g/mol
Synonyms	Amberketal; (1R,4S,E)-1-(2,6,6-Trimethyl-7-oxabicyclo[2.2.1]hept-2-en-1-yl)but-2-en-1-one; (E)-1-[(1R,4S)-2,6,6-Trimethyl-7-oxabicyclo[2.2.1]hept-2-en-1-yl]but-2-en-1-one; 7-Oxabicyclo[2.2.1]hept-2-ene-1-butanoic acid, 2,6,6-trimethyl-, (1R,4S,E)-; (1R,4S,E)-2,6,6-Trimethyl-7-oxabicyclo[2.2.1]hept-2-ene-1-butanoic acid
EINECS	Contact for details

Quality Control

Our (E)-1-[(1R,4S)-2,6,6-Trimethyl-7-oxabicyclo[2.2.1]hept-2-en-1-yl]-2-buten-1-one is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure high chemical and isomeric purity suitable for demanding applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Refractive Index	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.