Description

[(5Z,7E)-9,10-Secocholesta-5,7,10(19)-Triene-3β,25,26-Triyl]Tris(Oxy)]Tris(Trimethylsilane) is a key synthetic intermediate and protected derivative of a vitamin D analog, specifically designed for advanced pharmaceutical research and development. This compound matters because it provides a stable, silyl-protected form crucial for multi-step organic synthesis, enabling precise chemical modifications while preserving sensitive functional groups. It is primarily needed by research chemists and process development scientists in the pharmaceutical and fine chemical industries working on novel therapeutics, particularly in the areas of bone metabolism, oncology, and immunology.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of advanced vitamin D analogs and secosteroids for drug discovery programs.
• Chemical Research: Used in academic and industrial laboratories to study structure-activity relationships (SAR) of vitamin D receptor (VDR) ligands.
• Process Chemistry: Serves as a protected precursor in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in related compound analysis.
• Biochemical Probe Development: Employed in the creation of labeled or modified probes for studying vitamin D metabolic pathways and signaling mechanisms.

Basic Information

Product Name	[(5Z,7E)-9,10-Secocholesta-5,7,10(19)-Triene-3β,25,26-Triyl]Tris(Oxy)]Tris(Trimethylsilane)
CAS No.	56009-11-1
Molecular Formula	C36H72O3Si3
Molecular Weight	637.2 g/mol
Synonyms	1α,25-Dihydroxyvitamin D3 Tris(trimethylsilyl) Ether; Tris-O-trimethylsilyl-1α,25-dihydroxycholecalciferol; Calcitriol Tris(trimethylsilyl) Ether; 1,25-(OH)2-D3 Tris-TMS Ether; (5Z,7E)-1α,25-Dihydroxy-9,10-secocholesta-5,7,10(19)-trien-3β-yl Tris(trimethylsilyl) Ether; 1α,25-Dihydroxyvitamin D3 TMS Derivative; 1,25-Dihydroxycholecalciferol Tris(trimethylsilyl) Derivative
EINECS	Contact for details

Quality Control

Our [(5Z,7E)-9,10-Secocholesta-5,7,10(19)-Triene-3β,25,26-Triyl]Tris(Oxy)]Tris(Trimethylsilane) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) in a cool, dry place. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.