Description

(-)-n-Methyl-n-(α-Methylphenethyl)-3-(4-Methoxyphenyl)-6-Oxo-1(6H)-Pyridazineacetamide is a specialized chiral pyridazine derivative of significant interest in advanced organic synthesis. This compound matters as a high-value building block or potential intermediate for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex molecules with specific stereochemistry.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new therapeutic agents, particularly in central nervous system (CNS) or cardiovascular drug discovery programs.
• Medicinal Chemistry Research: Used as a scaffold or precursor for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Asymmetric Synthesis: Employed in chiral pool synthesis or as a starting material for constructing complex, enantiomerically pure molecules due to its defined stereocenter.
• Process Chemistry Development: Acts as a critical intermediate in scaling up synthetic routes from laboratory to pilot plant or commercial production.
• Reference Standard: Utilized as an analytical standard for quality control, method development, and regulatory submissions in pharmaceutical manufacturing.
• Fine Chemical Synthesis: Applied in the custom synthesis of specialty chemicals for agrochemical, material science, or other high-tech industries.

Basic Information

Product Name	(-)-n-Methyl-n-(α-Methylphenethyl)-3-(4-Methoxyphenyl)-6-Oxo-1(6H)-Pyridazineacetamide
CAS No.	55902-05-1
Molecular Formula	C24H27N3O3
Molecular Weight	405.49 g/mol
Synonyms	(-)-N-Methyl-N-(α-methylphenethyl)-3-(4-methoxyphenyl)-6-oxo-1(6H)-pyridazineacetamide; (S)-N-Methyl-N-(1-phenylethyl)-3-(4-methoxyphenyl)-6-oxo-1,6-dihydropyridazine-1-acetamide; L-741,626; L741626; 1(6H)-Pyridazineacetamide, N-methyl-N-(1-methyl-2-phenylethyl)-3-(4-methoxyphenyl)-6-oxo-, (αS)-; (-)-L-741,626; A potential dopamine D4 receptor antagonist intermediate.
EINECS	Contact for details

Quality Control

Our (-)-n-Methyl-n-(α-Methylphenethyl)-3-(4-Methoxyphenyl)-6-Oxo-1(6H)-Pyridazineacetamide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.