Description

Phosphoric Acid Bis(Trimethylsilyl)[2-(Trimethylsilyloxy)Ethyl] Ester is a specialized organosilicon reagent featuring a unique phosphoric acid core protected by multiple trimethylsilyl groups. This compound is valued for its role as a versatile silylating agent and a key synthetic intermediate in advanced organic synthesis. It is primarily sought after by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures and protecting sensitive functional groups.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing phosphate or protected phosphate ester functionalities.
• Silylating Agent: Employed to protect hydroxyl groups in complex multi-step organic syntheses, offering selective reactivity.
• Agrochemical Synthesis: Serves as a key building block in the production of specialized herbicides, insecticides, and plant growth regulators.
• Polymer & Materials Science: Utilized in the modification of polymer surfaces and the creation of novel silicon-containing hybrid materials.
• Nucleotide & Oligonucleotide Chemistry: Acts as a reagent in the preparation of modified nucleotides and during solid-phase oligonucleotide synthesis.
• Catalyst & Ligand Preparation: Used in the development of novel organometallic catalysts and ligands for asymmetric synthesis.
• Analytical Derivatization: Applied to derivative polar compounds for Gas Chromatography (GC) or Mass Spectrometry (MS) analysis to improve volatility and detection.
• Cross-Coupling Reactions: Functions as a phosphorus source or a unique ligand precursor in metal-catalyzed cross-coupling reactions.

Basic Information

Product Name	Phosphoric Acid Bis(Trimethylsilyl)[2-(Trimethylsilyloxy)Ethyl] Ester
CAS No.	55887-73-5
Molecular Formula	C11H29O4PSi3
Molecular Weight	340.58 g/mol
Synonyms	2-[(Bis(trimethylsilyl)phosphono)oxy]ethyl trimethylsilyl ether; Tris(trimethylsilyl) 2-(trimethylsilyloxy)ethyl phosphate; Phosphoric acid tris(trimethylsilyl) 2-(trimethylsilyloxy)ethyl ester; O,O-Bis(trimethylsilyl) O-[2-(trimethylsilyloxy)ethyl] phosphate; 2-(Trimethylsilyloxy)ethyl bis(trimethylsilyl) phosphate; TMS-protected 2-hydroxyethyl phosphate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with customer specifications. Quality assurance protocols include advanced analytical techniques such as NMR, GC, and HPLC to verify identity, purity, and the absence of critical impurities. A Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.