Description

(5Z,7E)-25-[(Trimethylsilyl)Oxy]-9,10-Secocholesta-5,7,10(19)-Triene-1,3β-Diol CAS NO 55759-94-9 is a key synthetic intermediate in the production of vitamin D analogs and other secosteroid derivatives. Its value lies in providing a protected and reactive scaffold for advanced pharmaceutical research and development. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors working on metabolic regulators, bone health therapeutics, and novel steroid-based compounds.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of active vitamin D metabolites (e.g., calcitriol, tacalcitol) and their analogs.
• Research & Development: Used in academic and industrial labs to study vitamin D receptor (VDR) activation and to develop new secosteroid-based drug candidates.
• Fine Chemical Synthesis: Serves as a versatile precursor for creating customized steroid structures with modified biological activity.
• Biochemical Tool Compound: Employed in metabolic pathway studies and as a reference standard in analytical method development for vitamin D analysis.

Basic Information

Product Name	(5Z,7E)-25-[(Trimethylsilyl)Oxy]-9,10-Secocholesta-5,7,10(19)-Triene-1,3β-Diol
CAS No.	55759-94-9
Molecular Formula	C30H52O3Si
Molecular Weight	488.82 g/mol
Synonyms	25-(Trimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene-1α,3β-diol; 1α,25-Dihydroxyvitamin D3 25-TMS Ether; 25-TMS-1α,25-(OH)2D3; (5Z,7E)-1α,3β-Dihydroxy-25-(trimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene; Vitamin D3 Derivative TMS Ether; 25-Trimethylsilyloxycalcitriol; Secosteroid TMS Intermediate
EINECS	Contact for details

Quality Control

Our (5Z,7E)-25-[(Trimethylsilyl)Oxy]-9,10-Secocholesta-5,7,10(19)-Triene-1,3β-Diol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The compound is light-sensitive and should be handled under controlled conditions to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.