Description

Methyl 2,3,5-Tri-o-Benzyl-β-D-Ribofuranoside is a key protected ribofuranoside derivative, serving as a critical synthetic intermediate in nucleoside chemistry. Its primary value lies in providing a versatile, benzyl-protected scaffold for the controlled synthesis of complex nucleosides, nucleotides, and their analogs. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing antiviral agents, anticancer drugs, and novel oligonucleotide therapeutics.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of modified nucleosides used in antiviral and anticancer drug discovery.
• Oligonucleotide Synthesis: Serves as a protected precursor for the preparation of ribonucleoside phosphoramidites, essential for solid-phase RNA synthesis.
• Prodrug Development: Used in the design and synthesis of prodrugs to enhance the bioavailability and targeting of nucleoside-based therapeutics.
• Biochemical Research: Employed in studies of RNA structure, function, and metabolism, as well as in enzyme inhibition assays.
• Labeled Compound Synthesis: Acts as a starting material for the preparation of isotopically labeled (e.g., 13C, 15N) nucleosides for metabolic tracing and NMR studies.
• Glycosylation Chemistry: A valuable substrate for studying and developing new glycosylation methodologies in carbohydrate chemistry.

Basic Information

Product Name	Methyl 2,3,5-Tri-o-Benzyl-β-D-Ribofuranoside
CAS No.	55725-85-4
Molecular Formula	C27H30O5
Molecular Weight	434.52 g/mol
Synonyms	Methyl 2,3,5-Tri-O-benzyl-β-D-ribofuranoside; 1-O-Methyl-2,3,5-tri-O-benzyl-β-D-ribofuranose; β-D-Ribofuranoside, methyl 2,3,5-tris-O-(phenylmethyl)-; Methyl 2,3,5-Tri-O-benzyl-D-ribofuranoside; 2,3,5-Tri-O-benzyl-1-O-methyl-β-D-ribofuranose; Methyl Tri-O-benzylribofuranoside; Protected Methyl Ribofuranoside; Benzyl-protected Ribose Derivative
EINECS	Contact for details

Quality Control

Our Methyl 2,3,5-Tri-o-Benzyl-β-D-Ribofuranoside is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and cGMP starting material applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant regulatory frameworks, including ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Melting Point	Contact for details
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.