Description

(E)-3-Tetrahydropyranyloxy-1-Tributylstannyl-1-Propene is a high-purity organotin reagent featuring a protected hydroxyl group, making it a versatile and critical building block in advanced organic synthesis. Its core value lies in enabling efficient Stille cross-coupling reactions, a powerful method for forming carbon-carbon bonds under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing complex drug candidates, particularly in the synthesis of molecules containing olefinic or aromatic segments via Stille coupling.
• Agrochemical Active Ingredient Development: Used in the research and production of novel pesticides and herbicides where specific carbon frameworks are required.
• Advanced Material Precursor: Serves as a building block for creating functional organic materials, including organic light-emitting diodes (OLEDs) and conductive polymers.
• Academic and R&D Laboratories: A valuable tool for methodological development in synthetic organic chemistry and catalysis studies.
• Fine Chemical Manufacturing: Employed in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Stille coupling reactions to introduce vinyl or aryl groups into target molecules.

Basic Information

Product Name	(E)-3-Tetrahydropyranyloxy-1-Tributylstannyl-1-Propene
CAS No.	55723-10-9
Molecular Formula	C20H40O2Sn
Molecular Weight	431.24 g/mol
Synonyms	1-Propene, 3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-(tributylstannyl)-, (1E)-; (E)-3-(Tetrahydro-2H-pyran-2-yloxy)-1-(tributylstannyl)-1-propene; 3-THPO-1-tributylstannyl-1-propene (E)-isomer; Tributyl[(3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-propen-1-yl)]stannane; THP-Protected Vinyltin Reagent; (E)-3-(Tetrahydropyran-2-yloxy)allyltributyltin; Allyltributyltin THP ether
EINECS	Contact for details

Quality Control

Our (E)-3-Tetrahydropyranyloxy-1-Tributylstannyl-1-Propene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is analyzed using advanced techniques including NMR (1H, 13C, 119Sn), GC, and HPLC to verify identity, purity, and the absence of critical impurities like tributyltin hydride. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C to minimize oxidation and degradation. Keep away from heat and incompatible materials such as strong oxidizing agents and acids.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0% (Area %)
Isomeric Purity (E/Z ratio)	≥ 98:2 (by GC or 1H NMR)
Tin (Sn) Content	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.