Description

4(3H)-Quinazolinone, 2-Methyl-3-[2-Methyl-3-[(Trimethylsilyl)Oxy]Phenyl]- is a specialized organosilicon-substituted quinazolinone derivative, serving as a key advanced intermediate in modern organic synthesis. Its value lies in providing a protected phenolic functionality and a heterocyclic core, enabling efficient construction of complex molecular architectures. This compound is primarily required by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing kinase inhibitory activity.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex heterocyclic compounds, leveraging its reactive quinazolinone and protected silyl ether groups.
• Agrochemical Development: Acts as a precursor in the design and synthesis of new herbicides, fungicides, or plant growth regulators that incorporate the quinazolinone pharmacophore.
• Material Science Precursor: Potential use in the development of organic electronic materials or metal-organic frameworks (MOFs) due to its conjugated system and functional handles.
• Chemical Biology Probe Synthesis: Utilized to create tagged or modified molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	4(3H)-Quinazolinone, 2-Methyl-3-[2-Methyl-3-[(Trimethylsilyl)Oxy]Phenyl]-
CAS No.	55683-28-8
Molecular Formula	C19H22N2O2Si
Molecular Weight	338.48 g/mol
Synonyms	2-Methyl-3-(2-methyl-3-(trimethylsilyloxy)phenyl)quinazolin-4(3H)-one; 3-(2-Methyl-3-((trimethylsilyl)oxy)phenyl)-2-methyl-4(3H)-quinazolinone; 2-Methyl-3-(2-methyl-3-(trimethylsiloxy)phenyl)-4(3H)-quinazolinone; TMS-protected Quinazolinone Derivative; 2-Methyl-3-(2-methyl-3-(TMS-oxy)phenyl)quinazolin-4-one
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research and development documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.