Description

(17R)-3-Cyclopentyloxy-11β-Methyl-19-Norpregna-1,3,5(10)-Trien-20-Yn-17-Ol CAS NO 55648-36-7 is a high-purity, synthetic steroid derivative with a complex, modified gonane structure. This compound is of significant value as a key pharmaceutical intermediate or reference standard in advanced research and development. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the synthesis and study of novel steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of novel steroid-based drug candidates targeting various endocrine pathways.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in pharmaceutical manufacturing and regulatory submissions.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate structure-activity relationships (SAR) of modified steroid molecules.
• Hormone Receptor Studies: Acts as a tool compound for probing the binding affinity and functional activity at steroid hormone receptors (e.g., androgen, progesterone receptors).
• Academic Synthesis: Used in university laboratories for teaching and research in advanced organic and medicinal chemistry, particularly in stereoselective synthesis.
• Process Chemistry Development: Supports the optimization of scalable and cost-effective synthetic routes for complex steroid analogs in pilot plants.

Basic Information

Product Name	(17R)-3-Cyclopentyloxy-11β-Methyl-19-Norpregna-1,3,5(10)-Trien-20-Yn-17-Ol
CAS No.	55648-36-7
Molecular Formula	C27H36O2
Molecular Weight	392.58 g/mol
Synonyms	11β-Methyl-19-nor-17α-pregna-1,3,5(10)-trien-20-yne-3,17-diol 3-cyclopentyl ether; 3-Cyclopentyloxy-11β-methyl-19-norpregna-1,3,5(10)-trien-20-yn-17-ol; 11β-Methyl-19-nor-17α-pregna-1,3,5(10)-trien-20-yn-3,17-diol 3-cyclopentyl ether; (17R)-11β-Methyl-19-norpregna-1,3,5(10)-trien-20-yn-3,17-diol 3-cyclopentyl ether; Tibolone intermediate; Livial intermediate; Org OD-14 intermediate; 7α-Methylnorethynodrel derivative.
EINECS	Contact for details

Quality Control

Our (17R)-3-Cyclopentyloxy-11β-Methyl-19-Norpregna-1,3,5(10)-Trien-20-Yn-17-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are provided and can be tailored to meet specific client or pharmacopeial requirements (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.