Description

(S)-2,2'-Binaphthyl-14-Crown-4 is a chiral crown ether derivative, specifically an enantiomerically pure (S)-configured ligand. This compound matters as a highly selective host molecule for the complexation of specific alkali metal cations, particularly lithium, enabling critical enantiomeric recognition and separation processes. Industries requiring advanced chiral resolution, asymmetric synthesis, or lithium isotope separation, such as pharmaceutical R&D, fine chemical manufacturing, and nuclear chemistry, are the primary users of this specialized material.

Application

• As a chiral selector in High-Performance Liquid Chromatography (HPLC) and Capillary Electrophoresis (CE) for the separation of enantiomers.
• As a key ligand in asymmetric phase-transfer catalysis for the synthesis of chiral pharmaceutical intermediates.
• For the selective extraction and membrane transport of lithium ions (Li⁺) in separation science and battery research.
• In the development of chiral molecular sensors and fluorescent probes for ion detection.
• As a building block for constructing more complex chiral supramolecular architectures and polymers.
• In fundamental research studying host-guest chemistry and enantioselective recognition mechanisms.

Basic Information

Product Name	(S)-2,2'-Binaphthyl-14-Crown-4
CAS No.	55442-00-7
Molecular Formula	C₂₈H₂₄O₄
Molecular Weight	424.49 g/mol
Synonyms	(S)-(-)-2,2'-Binaphthyl-14-crown-4; (S)-1,1'-Binaphthalene-2,2'-diyl 14-crown-4; (S)-BINOL-14-Crown-4; (S)-(-)-1,1'-Binaphthyl-14-Crown-4 Ether; (S)-BINAP-14-Crown-4 (common misnomer); (S)-1,1'-Bi-2-naphthol crown ether derivative; (S)-14-Crown-4 ether linked binaphthyl; (S)-Chiral 14-Crown-4
EINECS	Contact for details

Quality Control

Our (S)-2,2'-Binaphthyl-14-Crown-4 is produced under strict quality management protocols. Each batch undergoes comprehensive analysis to ensure high chemical and optical purity, with specifications typically meeting or exceeding research-grade standards. A Certificate of Analysis (COA) detailing chiral purity (enantiomeric excess), assay, and identification is provided to guarantee reproducible performance in sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to prevent potential oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% e.e.
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.