Description

n-[(Pentafluorophenyl)Methylene]-4-[(Trimethylsilyl)Oxy]Benzeneethanamine is a specialized organosilicon compound featuring a pentafluorophenyl and a protected phenolic group, making it a valuable advanced intermediate for pharmaceutical and materials science research. Its unique structure provides a versatile platform for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and high-performance polymers. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorinated and silyl-protected motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides where the pentafluorophenyl group can influence biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, resins, and coatings with tailored thermal and chemical resistance properties.
• Ligand Synthesis: Employed in the preparation of sophisticated ligands for catalysis, leveraging the electron-withdrawing nature of the pentafluorophenyl group to modulate metal center reactivity.
• Fluorinated Compound Library Development: A critical reagent for medicinal chemistry teams building diverse compound libraries for high-throughput screening (HTS) campaigns.
• Protecting Group Strategy: The trimethylsilyloxy (OTMS) group acts as a protective moiety for phenols during multi-step synthetic sequences.

Basic Information

Product Name	n-[(Pentafluorophenyl)Methylene]-4-[(Trimethylsilyl)Oxy]Benzeneethanamine
CAS No.	55334-64-0
Molecular Formula	C16H16F5NOSi
Molecular Weight	361.39 g/mol
Synonyms	4-[(Trimethylsilyl)oxy]-N-[(2,3,4,5,6-pentafluorophenyl)methylene]benzenethanamine; N-[(Pentafluorobenzylidene)]-4-(trimethylsiloxy)phenethylamine; 55334-64-0; Pentafluorobenzylidene-protected TMS-phenethylamine; (4-Trimethylsilyloxyphenyl)-N-(pentafluorobenzylidene)ethylamine; TMS-Protected Pentafluorobenzylidene Phenethylamine; PFB-TMS-Phenethylamine Schiff Base
EINECS	Contact for details

Quality Control

Our n-[(Pentafluorophenyl)Methylene]-4-[(Trimethylsilyl)Oxy]Benzeneethanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for research and development under cGMP-like controls where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.