Description

2-O,3-O,4-o-Tris(Trimethylsilyl)-5-o-[Bis(Trimethylsilyloxy)Phosphinyl]-D-Ribose o-Methyl Oxime is a highly functionalized, silyl-protected nucleoside derivative that serves as a critical synthetic intermediate. Its value lies in providing a protected and activated ribose scaffold for the controlled synthesis of complex nucleotides, nucleoside analogs, and oligonucleotides. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly in the creation of antiviral and anticancer agents, as well as in advanced biochemical research and process chemistry.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleoside-based therapeutics, including antiviral and anticancer drugs.
• Oligonucleotide Synthesis: Used in the preparation of modified oligonucleotides for antisense therapy, siRNA, and diagnostic probes.
• Biochemical Research: Serves as a precursor for labeled nucleotides or nucleotide analogs used in metabolic studies and enzyme assays.
• Process Chemistry: Employed in scalable routes for the production of high-value nucleoside active pharmaceutical ingredients (APIs).
• Protecting Group Strategy: The trimethylsilyl (TMS) groups allow for selective deprotection and further functionalization in multi-step synthetic sequences.
• Chemical Biology Tool Development: Useful for creating chemical probes to study nucleic acid interactions and related biological pathways.

Basic Information

Item	Details
Product Name	2-O,3-O,4-o-Tris(Trimethylsilyl)-5-o-[Bis(Trimethylsilyloxy)Phosphinyl]-D-Ribose o-Methyl Oxime
CAS No.	55319-74-9
Molecular Formula	C20H51N2O7PSi5
Molecular Weight	603.13 g/mol
Synonyms	D-Ribose, 2,3,4-tris-O-(trimethylsilyl)-5-O-[bis(trimethylsilyloxy)phosphinyl]-, O-methyloxime; 5-O-[Bis(trimethylsilyloxy)phosphinyl]-2,3,4-tris-O-(trimethylsilyl)-D-ribose O-methyloxime; TMS-protected ribose phosphonate oxime; Silylated ribofuranose derivative; Nucleoside synthesis intermediate; CAS 55319-74-9
EINECS	Contact for details

Quality Control

Our 2-O,3-O,4-o-Tris(Trimethylsilyl)-5-o-[Bis(Trimethylsilyloxy)Phosphinyl]-D-Ribose o-Methyl Oxime is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), identity (NMR/IR), and impurity profiles are provided with every shipment. We support development and production needs from research to commercial scale with reliable quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (by GC/HPLC)	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.