Description

1-(Trimethylsilyl)-1H-Indole-2-Carboxylic Acid Trimethylsilyl Ester is a highly functionalized, silyl-protected indole derivative that serves as a versatile and reactive synthetic intermediate. Its dual silyl protection on both the nitrogen and carboxylic acid functionalities makes it a critical building block for constructing complex heterocyclic systems with precise regiocontrol. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Synthesis: Building block for developing new generation herbicides, fungicides, and plant growth regulators with enhanced activity.
• Material Science: Used in the research and development of organic semiconductors, liquid crystals, and advanced polymers.
• Organic Synthesis: Acts as a protected glycine equivalent or a masked indole-2-carboxylate for complex multi-step reactions, including palladium-catalyzed cross-couplings.
• Research & Development: Valuable reagent in academic and industrial R&D labs for methodology development and exploring new chemical space.
• Fine Chemical Production: Intermediate in the custom synthesis of specialty chemicals and complex organic molecules for various high-value applications.

Basic Information

Product Name	1-(Trimethylsilyl)-1H-Indole-2-Carboxylic Acid Trimethylsilyl Ester
CAS No.	55255-80-6
Molecular Formula	C16H25NO2Si2
Molecular Weight	319.55 g/mol
Synonyms	Indole-2-carboxylic acid, 1-(trimethylsilyl)-, trimethylsilyl ester; 1-Trimethylsilylindole-2-carboxylic acid trimethylsilyl ester; 1-TMS-indole-2-carboxylic acid TMS ester; 1-(Trimethylsilyl)-1H-indole-2-carboxylic acid trimethylsilyl ester; 2-(Trimethylsiloxycarbonyl)-1-(trimethylsilyl)indole; 1H-Indole-2-carboxylic acid, 1-(trimethylsilyl)-, trimethylsilyl ester; TMS-Indole-2-COOTMS
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-1H-Indole-2-Carboxylic Acid Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and internal quality standards. Custom purity grades and analytical packages are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is sensitive to strong alkali and should be kept away from basic conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.