Description

2,4-Bis(Trimethylsilyloxy)Butyric Acid Trimethylsilyl Ester is a specialized organosilicon compound primarily used as a versatile protecting group reagent and synthetic intermediate in advanced organic synthesis. Its value lies in its ability to simultaneously protect multiple functional groups, streamlining complex multi-step reaction sequences and improving yields. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries developing active pharmaceutical ingredients (APIs), complex natural products, and novel materials.

Application

• Pharmaceutical Synthesis: Key protecting group reagent for hydroxyl and carboxyl functions in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used to protect sensitive amino acid side chains during solid-phase and solution-phase peptide synthesis.
• Natural Product Synthesis: Facilitates the synthesis of complex natural products by providing orthogonal protection strategies for polyfunctional intermediates.
• Fine Chemical Manufacturing: Serves as a crucial building block and intermediate in the production of specialty chemicals, agrochemicals, and performance materials.
• Process Chemistry & Scale-up: Enables efficient and scalable protection/deprotection strategies in pilot plant and commercial manufacturing processes.
• Research & Development: A valuable tool for medicinal chemists and process chemists in exploratory synthesis and route scouting for new chemical entities.

Basic Information

Product Name	2,4-Bis(Trimethylsilyloxy)Butyric Acid Trimethylsilyl Ester
CAS No.	55191-52-1
Molecular Formula	C13H32O4Si3
Molecular Weight	336.66 g/mol
Synonyms	2,4-Bis[(trimethylsilyl)oxy]butanoic Acid Trimethylsilyl Ester; Butanoic Acid, 2,4-Bis[(trimethylsilyl)oxy]-, Trimethylsilyl Ester; 2,4-Bis(trimethylsiloxy)butyric Acid Trimethylsilyl Ester; TMS-Protected 2,4-Dihydroxybutyrate; Tris(trimethylsilyl) 2,4-Dihydroxybutyrate; 55191-52-1; 2,4-Bis-O-TMS Butyric Acid TMS Ester
EINECS	Contact for details

Quality Control

Our 2,4-Bis(Trimethylsilyloxy)Butyric Acid Trimethylsilyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) with full traceability are provided for each lot, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.