Description

(R)-(-)-Dihydro-5-(Hydroxymethyl)-2(3H)-Furanone CAS NO 55094-96-7 is a high-purity chiral lactone building block, valued for its role as a versatile synthon in asymmetric synthesis. Its significance lies in providing a stereochemically defined scaffold for constructing complex pharmaceutical intermediates and fine chemicals. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific stereochemistry into their target molecules.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral, cardiovascular, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Flavor and Fragrance Ingredient: Serves as a building block for creating natural-identical flavor compounds and aroma chemicals.
• Asymmetric Catalysis Ligand Synthesis: Employed in the preparation of chiral ligands and organocatalysts for stereoselective transformations.
• Polymer Chemistry: Acts as a monomer or co-monomer for synthesizing biodegradable or functional polymers with specific optical properties.
• Academic and R&D: A valuable tool for methodological development in organic synthesis and medicinal chemistry research within university and corporate laboratories.

Basic Information

Product Name	(R)-(-)-Dihydro-5-(Hydroxymethyl)-2(3H)-Furanone
CAS No.	55094-96-7
Molecular Formula	C5H8O3
Molecular Weight	116.12 g/mol
Synonyms	(R)-(-)-Pantolactone; (R)-(-)-Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone (common mis-assignment, often used interchangeably); (R)-Pantolactone; (R)-3-Hydroxy-4,4-dimethyl-dihydrofuran-2(3H)-one; (3R)-3-Hydroxy-4,4-dimethyloxolan-2-one; (R)-(-)-3-Hydroxy-4,4-dimethylbutyrolactone; (R)-(-)-Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone; (R)-(-)-α-Hydroxy-β,β-dimethyl-γ-butyrolactone
EINECS	259-515-5

Quality Control

Our (R)-(-)-Dihydro-5-(Hydroxymethyl)-2(3H)-Furanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, assay, enantiomeric excess, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	91 - 94 °C
Specific Rotation [α]20/D	-49.0° to -51.0° (c=1 in H2O)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.