Description

4-Bromo-3-Methyl-5-Trimethylsilanyl-Isoxazole is a versatile organosilicon-protected isoxazole derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the strategic combination of a reactive bromine substituent and a stable trimethylsilyl (TMS) protecting group, enabling precise, multi-step molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors who require high-purity building blocks for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex heterocyclic compounds with potential biological activity.
• Agrochemical Research: Used in creating novel pesticide and herbicide candidates by functionalizing the isoxazole core.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and silicon-containing materials.
• Organic Synthesis Reagent: Utilized in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to the reactive bromine atom.
• Chemical Library Development: Employed in combinatorial and parallel synthesis for high-throughput screening of new chemical entities.
• Protecting Group Strategy: The TMS group can be selectively removed under mild conditions, allowing for sequential synthesis.

Basic Information

Product Name	4-Bromo-3-Methyl-5-Trimethylsilanyl-Isoxazole
CAS No.	54773-30-7
Molecular Formula	C8H14BrNOSi
Molecular Weight	248.20 g/mol
Synonyms	5-(Trimethylsilyl)-4-bromo-3-methylisoxazole; 4-Bromo-3-methyl-5-(trimethylsilyl)isoxazole; 3-Methyl-4-bromo-5-trimethylsilylisoxazole; 4-Bromo-3-methyl-5-(trimethylsilyl)-1,2-oxazole; Isoxazole, 4-bromo-3-methyl-5-(trimethylsilyl)-; TMS-Protected 4-Bromo-3-methylisoxazole
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-3-Methyl-5-Trimethylsilanyl-Isoxazole is produced and tested under strict quality management protocols to ensure consistency and reliability for your synthetic workflows. Our standard grade meets high-purity specifications suitable for research and development, with Certificates of Analysis (COA) provided for each shipment, detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and custom synthesis with tailored purity grades (e.g., >98%, >99%) is available upon request to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.