Description

3-(2-Pyridyl)Acrylic Acid, Predominantly Trans is a versatile organic building block featuring a pyridine ring conjugated to an acrylic acid moiety. This compound matters as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research, due to its reactive carboxylic acid and unsaturated alkene functionalities. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing heterocyclic compounds and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing pyridine-based heterocycles.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the pyridylacrylic acid scaffold imparts specific biological activity.
• Ligand and Chelating Agent: Serves as a starting material for creating polydentate ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the development of organic semiconductors, conductive polymers, and photoactive materials due to its conjugated system.
• Cross-coupling Reactions: Acts as a substrate in various palladium-catalyzed cross-coupling reactions (e.g., Heck, Suzuki) to create more complex molecular architectures.
• Fine Chemical Production: Utilized as a specialty intermediate for manufacturing dyes, pigments, and other performance chemicals.

Basic Information

Product Name	3-(2-Pyridyl)Acrylic Acid, Predominantly Trans
CAS No.	54495-51-1
Molecular Formula	C8H7NO2
Molecular Weight	149.15 g/mol
Synonyms	trans-3-(2-Pyridyl)acrylic acid; (E)-3-(Pyridin-2-yl)acrylic acid; 2-Pyridineacrylic acid; β-(2-Pyridyl)acrylic acid; 3-(2-Pyridinyl)-2-propenoic acid; (E)-3-(2-Pyridinyl)-2-propenoic acid; 2-Propenoic acid, 3-(2-pyridinyl)-, (E)-; Pyridine-2-acrylic acid
EINECS	Contact for details

Quality Control

Our 3-(2-Pyridyl)Acrylic Acid undergoes rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques including HPLC, NMR, and GC to verify identity, purity, and isomeric composition. Certificates of Analysis (COA) detailing batch-specific results are available upon request. Our quality management system supports production under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container should be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (trans)	≥ 95.0%
Melting Point	185 - 190 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.