Description

α-(tert-Butyl)Hydrocinnamic Acid is a versatile organic acid derivative characterized by its unique sterically hindered structure. This compound serves as a valuable chiral building block and intermediate in advanced organic synthesis, where its tert-butyl group provides significant control over reaction pathways. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical and fine chemical sectors for developing active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) and other active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Employed as a building block for constructing complex, stereochemically defined molecules in medicinal chemistry and total synthesis projects.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis, enhancing selectivity in chemical transformations.
• Fine Chemical Production: Intermediate for manufacturing specialty chemicals, including flavors, fragrances, and advanced materials.
• Academic and R&D: Serves as a standard or starting material in chemical research for method development and exploring new synthetic routes.

Basic Information

Product Name	α-(tert-Butyl)Hydrocinnamic Acid
CAS No.	53483-12-8
Molecular Formula	C₁₃H₁₈O₂
Molecular Weight	206.28 g/mol
Synonyms	2-(4-tert-Butylphenyl)propanoic Acid; 2-(p-tert-Butylphenyl)propionic Acid; α-(tert-Butyl)phenylpropionic Acid; (RS)-2-(4-tert-Butylphenyl)propanoic Acid; (±)-2-(4-tert-Butylphenyl)propanoic Acid; 4-tert-Butylhydratropic Acid; NSC 163022
EINECS	Contact for details

Quality Control

Our α-(tert-Butyl)Hydrocinnamic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to minimize exposure to atmospheric humidity. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	85 - 89 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.