Description

(S)-(-)-6-Hydroxy-2,5,7,8-Tetramethylchroman-2-Carboxylic Acid is a high-purity, single-enantiomer compound belonging to the chroman carboxylic acid family, serving as a key chiral intermediate and reference standard. Its primary value lies in its potent antioxidant properties and its role as a critical building block for synthesizing more complex, biologically active molecules. This material is essential for research and development in the pharmaceutical, nutraceutical, and fine chemical industries, where precise stereochemistry and high purity are paramount for efficacy and regulatory compliance.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the development of novel therapeutic agents, particularly those targeting oxidative stress.
• Antioxidant Research: Used as a reference standard and active component in studies investigating cellular protection against free radicals.
• Nutraceutical Formulation: Employed in the development of advanced dietary supplements and cosmeceuticals for its stable antioxidant activity.
• Fine Chemical Synthesis: Serves as a specialized starting material for synthesizing derivatives with enhanced or modified biological activity.
• Analytical Standard: Provides a high-purity benchmark for quality control and method development in analytical laboratories (HPLC, GC).
• Biochemical Research: Utilized in enzymatic and metabolic pathway studies related to redox biology and aging.

Basic Information

Product Name	(S)-(-)-6-Hydroxy-2,5,7,8-Tetramethylchroman-2-Carboxylic Acid
CAS No.	53174-06-4
Molecular Formula	C14H18O4
Molecular Weight	250.29 g/mol
Synonyms	(S)-Trolox; (S)-(-)-Trolox; (S)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; (S)-Vitamin E water-soluble analog; (2S)-6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylic acid; (S)-Hydroxytrolox; (S)-Trolox acid; (S)-enantiomer of Trolox
EINECS	Contact for details

Quality Control

Our (S)-(-)-6-Hydroxy-2,5,7,8-Tetramethylchroman-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical and research applications. Certificates of Analysis (COA) documenting identity, purity, enantiomeric excess, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.