Description

(5S,6S)-5,6-Dihydro-5-Hydroxy-4-Methoxy-6-[(E)-2-Phenylethenyl]-2H-Pyran-2-One is a high-purity, stereochemically defined lactone derivative with significant synthetic utility. This compound serves as a versatile chiral building block and intermediate for the synthesis of complex natural products and biologically active molecules. It is particularly valuable for pharmaceutical research and development in medicinal chemistry, as well as for advanced organic synthesis in fine chemical production.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry: Used in the synthesis of complex molecular scaffolds for drug discovery programs targeting various therapeutic areas.
• Natural Product Synthesis: A critical intermediate in the total synthesis of natural products containing dihydropyranone moieties.
• Asymmetric Synthesis: Employed as a precursor or reagent in stereoselective chemical transformations.
• Fine Chemical Production: Serves as a building block for the manufacture of specialty chemicals, flavors, and fragrances.
• Academic & Industrial R&D: Used in research laboratories for methodological development and the exploration of new chemical reactions.

Basic Information

Product Name	(5S,6S)-5,6-Dihydro-5-Hydroxy-4-Methoxy-6-[(E)-2-Phenylethenyl]-2H-Pyran-2-One
CAS No.	52247-80-0
Molecular Formula	C₁₅H₁₆O₄
Molecular Weight	260.29 g/mol
Synonyms	(5S,6S)-5,6-Dihydro-5-hydroxy-4-methoxy-6-[(E)-2-phenylethenyl]-2H-pyran-2-one; 5,6-Dihydro-5-hydroxy-4-methoxy-6-styryl-2H-pyran-2-one (5S,6S)-; (5S,6S)-5,6-Dihydro-5-hydroxy-4-methoxy-6-styryl-2H-pyran-2-one; (5S,6S)-6-[(E)-Styryl]-5,6-dihydro-5-hydroxy-4-methoxy-2H-pyran-2-one; 2H-Pyran-2-one, 5,6-dihydro-5-hydroxy-4-methoxy-6-[(E)-2-phenylethenyl]-, (5S,6S)-; (5S,6S)-6-Styryldihydro-5-hydroxy-4-methoxy-2-pyrone
EINECS	Contact for details

Quality Control

Our (5S,6S)-5,6-Dihydro-5-Hydroxy-4-Methoxy-6-[(E)-2-Phenylethenyl]-2H-Pyran-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent oxidation and moisture uptake. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.