Description

4-(Toluenesulphonyl)Nitromethane is a specialized organic compound with the CAS number 51351-89-4, serving as a valuable building block in advanced chemical synthesis. This compound is particularly significant for its role as a functionalized nitromethane derivative, offering a reactive nitro group tethered to a tosyl-protected moiety. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring nitroalkane or sulfonamide functionalities.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, insecticides, and fungicides where its specific reactivity profile is advantageous.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for Michael additions, Henry reactions, and as a precursor to amines and other nitrogen-containing compounds.
• Material Science Research: Investigated for the development of specialty polymers, energetic materials, and ligands for catalysis due to its unique chemical structure.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.

Basic Information

Product Name	4-(Toluenesulphonyl)Nitromethane
CAS No.	51351-89-4
Molecular Formula	C8H9NO4S
Molecular Weight	215.22 g/mol
Synonyms	p-Toluenesulfonylnitromethane; (4-Methylphenyl)sulfonylnitromethane; Tosylnitromethane; Nitro(p-tolylsulfonyl)methane; 4-Methylbenzenesulfonylnitromethane; α-Nitro-p-toluenesulfonylmethane; 1-Nitro-1-(p-tolylsulfonyl)methane; 51351-89-4
EINECS	Contact for details

Quality Control

Our 4-(Toluenesulphonyl)Nitromethane is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with key parameters including assay (by HPLC), identification (IR, NMR), and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light and moisture sources to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.