Description

(1R,2R)-1,2,3,6-Tetrahydrophthalic Acid CAS NO 50987-15-0 is a high-purity, stereochemically defined chiral dicarboxylic acid derivative. This compound serves as a critical chiral building block and resolving agent in the synthesis of advanced pharmaceuticals and fine chemicals. It is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries where precise stereochemistry is required for biological activity or material properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) drug candidates.
• Chiral Resolution Agent: Used to separate enantiomers of racemic mixtures through diastereomeric salt formation, a critical process in asymmetric synthesis.
• Fine Chemical Synthesis: Employed in the production of chiral ligands, catalysts, and other high-value specialty chemicals.
• Polymer Chemistry: Acts as a monomer or modifier in the synthesis of specialized polymers with tailored properties, such as epoxy resin hardeners.
• Agrochemical Research: Utilized in the development of chiral pesticides and herbicides where specific enantiomer activity is targeted.
• Academic & R&D: Serves as a standard and reagent in university and corporate research laboratories for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	(1R,2R)-1,2,3,6-Tetrahydrophthalic Acid
CAS No.	50987-15-0
Molecular Formula	C8H10O4
Molecular Weight	170.16 g/mol
Synonyms	(1R,2R)-1,2,3,6-Tetrahydrophthalic Acid; (1R,2R)-Cyclohex-4-ene-1,2-dicarboxylic Acid; (-)-(1R,2R)-1,2,3,6-Tetrahydrophthalic Acid; (1R,2R)-4-Cyclohexene-1,2-dicarboxylic Acid; L-(-)-1,2,3,6-Tetrahydrophthalic Acid; (1R,2R)-1,2,3,6-Tetrahydrobenzene-1,2-dicarboxylic Acid
EINECS	Contact for details

Quality Control

Our (1R,2R)-1,2,3,6-Tetrahydrophthalic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity (enantiomeric excess) and chemical purity assays, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.