Description

m-Peg3-Tos CAS NO 50586-80-6 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a tosylate (p-toluenesulfonate) group at one terminus and a methoxy group at the other. This compound is a critical intermediate in the synthesis of complex molecules, enabling the controlled introduction of PEG chains to enhance solubility, reduce immunogenicity, and improve pharmacokinetic properties. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for developing novel therapeutics and functionalized polymers.

Application

• Pharmaceutical Linker: A key building block for creating antibody-drug conjugates (ADCs), peptide-drug conjugates, and other targeted therapeutic agents.
• PEGylation Reagent: Used to PEGylate proteins, peptides, and small molecule drugs to improve their stability, solubility, and circulation half-life in the body.
• Polymer Chemistry: Serves as a functional initiator or monomer in the synthesis of tailored block copolymers and functionalized hydrogels for drug delivery systems.
• Bioconjugation: Facilitates the site-specific attachment of drugs, labels, or other functional molecules to biomolecules like antibodies or enzymes.
• Surface Modification: Employed to functionalize nanoparticles, quantum dots, and other material surfaces with PEG chains for improved biocompatibility and stealth properties.
• Cross-linking Agent: Acts as a spacer or cross-linker in the development of diagnostic assays and biosensor platforms.

Basic Information

Product Name	m-Peg3-Tos
CAS No.	50586-80-6
Molecular Formula	C17H28O7S
Molecular Weight	376.47 g/mol
Synonyms	2,5,8,11-Tetraoxatridecan-13-yl 4-methylbenzenesulfonate; Methoxy-PEG3-tosylate; mPEG3-OTs; 1-(Methoxy(triethyleneoxy))-4-toluenesulfonate; 3,6,9-Trioxaundecan-1-yl 11-(4-methylphenyl)sulfonate; PEG3 methyl ether tosylate; m-PEG3-OTs; α-Methoxy-ω-tosyl-poly(ethylene glycol)
EINECS	Contact for details

Quality Control

Our m-Peg3-Tos is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring material for GLP or GMP workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.