Description

Methyl p-Toluenesulphonylacetate is a versatile organic sulfonate ester, widely recognized as a key building block in synthetic organic chemistry. Its primary value lies in its role as a reactive intermediate for introducing the p-toluenesulfonyl (tosyl) protected acetamide or ester moiety, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in the synthesis of complex molecules, active pharmaceutical ingredients (APIs), and fine chemicals.

Application

• Pharmaceutical Intermediates: A critical precursor in the multi-step synthesis of various drug candidates and active pharmaceutical ingredients (APIs), particularly those requiring sulfonamide or protected carboxylic acid functionalities.
• Agrochemical Synthesis: Used in the development and production of advanced herbicides, fungicides, and insecticides where its sulfonyl group contributes to biological activity.
• Peptide Chemistry: Serves as a protecting group reagent or a coupling agent in the synthesis of modified peptides and peptidomimetics.
• Polymer & Material Science: Employed as a monomer or cross-linking agent in the production of specialty polymers, resins, and functional materials.
• Organic Synthesis Reagent: Utilized in various name reactions and transformations, such as alkylations and Michael additions, as a source of the tosylmethyl or activated methylene group.
• Dye & Pigment Manufacturing: Acts as an intermediate in the synthesis of complex organic dyes, pigments, and optical brighteners.

Basic Information

Product Name	Methyl p-Toluenesulphonylacetate
CAS No.	50397-64-3
Molecular Formula	C10H12O4S
Molecular Weight	228.26 g/mol
Synonyms	Methyl (4-methylphenyl)sulfonylacetate; Methyl (p-tolylsulfonyl)acetate; p-Toluenesulfonylacetic acid methyl ester; Tosylacetic acid methyl ester; Methyl tosylacetate; Methyl (tosyl)acetate; 2-(4-Methylbenzenesulfonyl)acetic acid methyl ester; Acetic acid, 2-[(4-methylphenyl)sulfonyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl p-Toluenesulphonylacetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee compliance with your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The compound is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	78 - 82 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.