Description

n-[(Pentafluorophenyl)Methylene]-3,4-Bis[(Trimethylsilyl)Oxy]Benzeneethanamine is a specialized organosilicon and fluorinated aromatic compound that serves as a high-value synthetic intermediate. Its molecular architecture, featuring both pentafluorophenyl and silyl-protected catechol moieties, makes it a critical building block for advanced materials and pharmaceutical research. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate unique fluorinated and silicon-containing functionalities into target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders or requiring enhanced metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorinated aromatic ring can improve biological activity and environmental persistence profiles.
• Ligand and Catalyst Development: Serves as a sophisticated precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Building block for advanced polymers, liquid crystals, or organic electronic materials where fluorine and silicon groups tune electronic properties and stability.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological systems due to its distinctive spectroscopic signature.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects requiring this precise chemical scaffold.

Basic Information

Product Name	n-[(Pentafluorophenyl)Methylene]-3,4-Bis[(Trimethylsilyl)Oxy]Benzeneethanamine
CAS No.	50314-21-1
Molecular Formula	C21H26F5NO2Si2
Molecular Weight	483.61 g/mol
Synonyms	1-[N-(Pentafluorobenzylidene)amino]-2-[3,4-bis(trimethylsilyloxy)phenyl]ethane; 2-[3,4-Bis(trimethylsiloxy)phenyl]-1-[(2,3,4,5,6-pentafluorobenzylidene)amino]ethane; N-(Pentafluorobenzylidene)-2-[3,4-bis(trimethylsilyloxy)phenyl]ethanamine; Pentafluorobenzylidene-protected dopamine silyl ether; PFB-Dopamine bis-TMS ether
EINECS	Contact for details

Quality Control

Every batch of n-[(Pentafluorophenyl)Methylene]-3,4-Bis[(Trimethylsilyl)Oxy]Benzeneethanamine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment aligns with cGMP principles where applicable for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation (IR, NMR), and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or inert gas when appropriate to prevent decomposition. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities	≤ 5.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.