Description

n-Mesitylenesulfonylimidazole (CAS NO 50257-39-1) is a specialized sulfonylation reagent widely used in organic synthesis for the protection of amines and alcohols. Its core value lies in its high reactivity and selectivity, making it an essential tool for constructing complex molecular architectures in a controlled manner. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for peptide synthesis, nucleoside chemistry, and the preparation of sensitive intermediates.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the sulfonylation of amines and hydroxyl groups in active pharmaceutical ingredient (API) development.
• Peptide Chemistry: Used as a coupling agent or protecting group reagent in solid-phase and solution-phase peptide synthesis.
• Nucleoside & Nucleotide Modification: Facilitates the introduction of sulfonyl protecting groups in the synthesis of modified nucleosides and oligonucleotides.
• Polymer Science: Employed in the synthesis of functional monomers and specialty polymers requiring selective protection/deprotection strategies.
• Agrochemical Research: Used in creating novel herbicide and pesticide intermediates through selective chemical transformations.
• Academic & Process R&D: A valuable reagent in methodological development and scale-up studies for complex organic molecules.

Basic Information

Product Name	n-Mesitylenesulfonylimidazole
CAS No.	50257-39-1
Molecular Formula	C12H14N2O2S
Molecular Weight	250.32 g/mol
Synonyms	Mesitylenesulfonylimidazole; 2,4,6-Trimethylbenzenesulfonylimidazole; Mesylimidazole; MSI; N-(Mesitylsulfonyl)imidazole; 1-(2,4,6-Trimethylphenylsulfonyl)-1H-imidazole; 1-Mesitylsulfonylimidazole; Trimethylbenzenesulfonylimidazole
EINECS	Contact for details

Quality Control

Our n-Mesitylenesulfonylimidazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	108 - 112 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.