Description

2-Amino-5-Chlorobenzonitrile is a versatile aromatic nitrile and aniline derivative that serves as a critical building block in advanced organic synthesis. Its bifunctional nature, featuring both an amino and a nitrile group on a chlorinated benzene ring, makes it a high-value intermediate for constructing complex molecular architectures. This compound is essential for research and production in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those with benzimidazole or quinazoline cores.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and insecticides, leveraging its halogen and amino groups for structural diversity.
• Dye and Pigment Manufacturing: Serves as a starting material for producing azo dyes and other complex colorants.
• Material Science: Employed in the research and development of organic semiconductors, liquid crystals, and polymers.
• Chemical Research: A valuable reagent for academic and industrial R&D in heterocyclic chemistry and medicinal chemistry.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions like Buchwald-Hartwig amination due to the presence of the amino and chloro groups.

Basic Information

Product Name	2-Amino-5-Chlorobenzonitrile
CAS No.	5922-60-1
Molecular Formula	C7H5ClN2
Molecular Weight	152.58 g/mol
Synonyms	5-Chloro-2-aminobenzonitrile; 2-Amino-5-chlorobenzene carbonitrile; 5-Chloroanthranilonitrile; 5-Chloro-2-cyanobenzenamine; Benzonitrile, 2-amino-5-chloro-; 2-Cyano-4-chloroaniline; 4-Chloro-2-cyanobenzenamine
EINECS	227-656-7

Quality Control

Our 2-Amino-5-Chlorobenzonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, GC, and NMR analyses. Our quality commitment ensures the material meets the stringent requirements for GMP-grade intermediates and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.