Description

1-(Chloromethyl)-2-Phenoxy-Benzene is a versatile chloromethylated aromatic ether building block of significant importance in advanced organic synthesis. Its reactive chloromethyl group makes it a key intermediate for constructing more complex molecular architectures through nucleophilic substitution and cross-coupling reactions. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly those with diphenyl ether or benzylamine pharmacophores.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators where the phenoxy-benzene scaffold is required.
• Ligand and Catalyst Development: Acts as a starting material for the preparation of specialized ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Polymer Modification: Employed to introduce reactive sites or functional groups into polymer chains for creating specialty resins and high-performance materials.
• Dye and Pigment Manufacturing: Utilized as an intermediate in the synthesis of complex organic dyes and colorants.
• Cross-coupling Reactions: The chloromethyl group can be transformed for use in Suzuki, Heck, and other palladium-catalyzed coupling reactions.

Basic Information

Product Name	1-(Chloromethyl)-2-Phenoxy-Benzene
CAS No.	5888-53-9
Molecular Formula	C₁₃H₁₁ClO
Molecular Weight	218.68 g/mol
Synonyms	2-Phenoxybenzyl Chloride; (2-Phenoxyphenyl)methyl Chloride; α-Chloro-2-phenoxytoluene; o-Phenoxybenzyl Chloride; 1-Chloromethyl-2-phenoxybenzene; Benzene, 1-(chloromethyl)-2-phenoxy-; NSC 403107
EINECS	227-557-5

Quality Control

Our 1-(Chloromethyl)-2-Phenoxy-Benzene is manufactured under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including chromatography and spectroscopy, to ensure identity, purity, and consistency meet the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.