Description

4-Methanesulfonyl-Benzamidine Hcl is a high-purity chemical building block and research compound. This sulfonyl-substituted benzamidine derivative is valued for its role as a key intermediate in the synthesis of biologically active molecules, particularly protease inhibitors. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel therapeutic agents. The compound's specific structure makes it a critical precursor for targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of serine protease inhibitors and other pharmacologically active compounds.
• Biochemical Research: Used as a tool compound in enzymatic studies and for probing the active sites of trypsin-like proteases.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies in drug discovery projects.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses to introduce the amidine functional group in complex molecules.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	4-Methanesulfonyl-Benzamidine Hcl
CAS No.	5434-06-0
Molecular Formula	C8H11ClN2O2S
Molecular Weight	234.70 g/mol
Synonyms	4-(Methylsulfonyl)benzamidine hydrochloride; p-Methanesulfonylbenzamidine hydrochloride; Benzenecarboximidamide, 4-(methylsulfonyl)-, hydrochloride (1:1); 4-Methylsulfonylbenzamidine HCl; 4-Mesylbenzamidine hydrochloride; 5434-06-0; Amidino-4-methylsulfonylbenzene hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Methanesulfonyl-Benzamidine Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements. Specifications are designed to meet the stringent demands of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.