Description

n-(4-Bromoacetyl)Phenyl-1-Butanesulfonamide is a specialized organic synthesis intermediate featuring a reactive bromoacetyl group and a sulfonamide moiety. This compound is valued for its role as a key building block in the development of more complex molecules, particularly in pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for creating potential drug candidates and biochemical probes.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel small-molecule therapeutics, particularly those targeting enzymes where the sulfonamide group acts as a pharmacophore.
• Bioconjugation & Probe Development: The reactive bromoacetyl group enables selective alkylation of thiol groups in proteins and peptides, making it useful for creating affinity labels, fluorescent probes, or antibody-drug conjugates (ADCs).
• Chemical Biology Research: Employed in the design and synthesis of activity-based probes (ABPs) to study enzyme function and mechanism in complex biological systems.
• Material Science Research: Can be used as a monomer or cross-linking agent in the development of specialized polymers with unique sulfonamide-based properties.
• Agrochemical Synthesis: Acts as an intermediate in the research and development of new crop protection agents and herbicides.

Basic Information

Product Name	n-(4-Bromoacetyl)Phenyl-1-Butanesulfonamide
CAS No.	5374-37-8
Molecular Formula	C₁₂H₁₆BrNO₃S
Molecular Weight	334.23 g/mol
Synonyms	4-Bromoacetyl-N-(4-sulfobutyl)aniline; 1-(4-((4-Sulfobutyl)amino)phenyl)-2-bromoethan-1-one; N-(4-Bromoacetylphenyl)butane-1-sulfonamide; 4'-Bromoacetophenone-4-sulfobutylamine; p-Bromoacetylphenylbutanesulfonamide; Bromoacetyl Sulfonamide Intermediate BPS-8; Butane-1-sulfonic acid [4-(2-bromoacetyl)phenyl]amide
EINECS	Contact for details

Quality Control

Every batch of n-(4-Bromoacetyl)Phenyl-1-Butanesulfonamide is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.